RAF Typhoon FGR4s have joined forces with France's air force in a coordinated attack targeting an hidden munitions depot in Syria employed by the IS group, as stated by the British defence ministry.
The site, identified by reconnaissance, was believed to be housing weapons and explosive materials, the announcement noted, and was positioned in mountainous terrain just above Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of entry passages leading to the depot... preliminary assessments are that the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the attack on Saturday evening and each participating jet made a safe return, the MoD added.
The British jets were backed up by a Voyager refuelling tanker.
Daesh - also known as ISIS - imposed extremist governance over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This action underscores our UK leadership, and resolve to stand shoulder to shoulder with our allies, to eradicate any re-emergence of IS and their dangerous and violent ideologies in the area," UK Defence Secretary the minister said.
RAF aircraft have carried out patrols over Syria to "deter any attempted comeback" of IS after its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank all the members of British forces who took part in this strike for their expertise and their courage," he said. "Including them were numerous UK service members deployed over the festive period. This action, to eliminate terrorist threats who endanger our safety, highlights how UK forces are ready to step up, throughout the year, keeping Britain secure within its borders and strong abroad."
Last December, the US military carried out what it called a "large-scale strike" against Islamic State objectives in the country, after an assault claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The United Nations says IS still has an estimated 5,000 to 7,000 combatants in both countries.
